Reader’s Choice 2012-13 Blog Post #1
Pulkit Khatri is currently in his second year of studies as a Ph.D. student of Industrial Pharmacy in the Department of Pharmaceutical Sciences at St. John’s University, mentored by Associate Professor Jun Shao.
Advancements in the development of recombinant proteins and peptides with therapeutic potential have dramatically changed the biotechnology and pharmaceutical market, but the requirements of parenteral delivery limits their usage. Therefore, there is great need for a noninvasive protein and peptide drug delivery system.
Oral administration is the most convenient route for patients. For protein and peptide delivery, however, this type of delivery has been a great challenge because of extensive degradation and limited absorption. To overcome these hurdles, several strategies have been developed and have achieved limited success. Some studies have shown that adequate absorption can be achieved if there is enough protein present on the absorption surface or if the enzyme degradation is inhibited. Therefore, a system that can continuously and directly release the protein on the absorption surface will increase the bioavailability. In addition, this will also minimize the protein exposure to the harsh intestinal environment.