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By: Rakesh Gollen and DILEEP R. JANAGAM

Rakesh Gollen

Regenerative therapy has evolved tremendously in recent years and is a promising approach in restoring the function of diseased, damaged, and aged tissues and organs. It is a highly interdisciplinary field that has been made possible by the intersection of recent advances in bioengineering, stem cell biology, and nanotechnology. Incorporation of nanotechnology allows better control over physical and biological properties of a biomaterial than conventional technologies.

Nanotechnology applications to regenerative therapy have all the potential to revolutionize tissue regeneration and repair, and ultimately personalized medicine by improving the biocompatibility between tissue and medical devices. Although nanotechnology has great potential to enhance regenerative therapy, it is still challenging to develop promising nanomaterials that can send signals to the diseased or damaged cells and tissues to trigger the regeneration process for its potential to treat a broad range of degenerative and ischemic diseases in tissues or organs including its application in skin replacement for burn victims and diabetics, bone and cartilage regenerations, bladder repair, repair of heart muscle after myocardial infraction etc.

In recent years, various attempts using nanotechnologies has been approached for material modification, knowing the fact that the extracelluar matrix (ECM) protein consists of nanoscale components, but the scientific community is finding it difficult to develop materials with superior biomimicking ability to native tissue or ECM protein in the internal milieu to promote regeneration. Further, there are considerable long-term and acute safety concerns regarding the use of nanomaterials in regenerative medicine in humans because of the nascent stage of the field as these nanomaterials have provided a preferentially control of the behavior and differentiation of cells. Still, there is a need for comprehensive understanding of the underlying mechanisms of interactions between cells/tissue with the biomaterials at the nanoscale level for tuning the materials.

Join me at the 2017 AAPS National Biotechnology Conference in San Diego for the symposium Future and Advances of Nanotechnology Enabled Regenerative Therapy to learn about new strategies and insights into nanotechnology and how it supplies an integrated approach that allows the use of nanotech tools in various clinical scenarios of regenerative therapy. Leading experts in the field will address recent developments, future directions, and possible challenges in advancing regenerative therapy using nanotechnology.

Please feel free to share your thoughts on this topic before or after the symposium via the comments section below. Happy learning!

Rakesh Gollen is an associate director (Clinical Pharmacology) at KinderPharm with dedication to “Bringing Better Medicines to Children of All Age Groups.”
Dileep R. Janagam, Ph.D. is a Senior Research Specialist at Plough Center for Sterile Drug Delivery Systems, University of Tennessee Health Science Center. His research interests include formulation development and drug delivery. Dr. Janagam holds a B.S. degree in Pharmacy, an M.S. degree in Chemistry, and a Ph.D. in Pharmaceutics.