The Movement of In Vivo Prediction by the In Vitro/In Silico Study: How Have We Been Doing?

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By Yasuhiro Tsume

Compendial in vitro dissolution methodologies such as USP I and II have been conducted to assure the quality of oral products and to perform the in vivo-in vitro correlation as well as predict in vivo drug dissolution of test oral products. However, the human gastrointestinal (GI) tract is far more complicated than the simplified compendial dissolution apparatuses. As a result, newer in vitro dissolution methodologies have to be developed in order to understand the in vivo performance of oral (test) formulations and to formulate the best oral products. Continue reading

Science of Presentation: The Art of Captivating People

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By Amruta Indapurkar

Presentations are a key requirement in a person’s professional life, whether a person is a business official presenting in a meeting, a keynote speaker addressing a large audience, or a graduate student reporting data in the department. In any of these cases, the outcome of a presentation will depend on a person’s presentation skills. As a graduate student, I have attended and given many presentations in different settings, and I have gradually learned some fundamental presentation skills. In this blog post, I would like to share some tips for an impressive presentation. Continue reading

Innovation and Discovery: How Scientific Inquiry Leads to Entrepreneurship

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By Brandon Lucke-Wold

The entrepreneurial spark started with a rock-climbing excursion with a friend, who happened to be another M.D./Ph.D. student. In between climbing routes, we began talking about how our research was going, and what limitations we were facing. It quickly became apparent that we were both struggling with similar technical limitations and that these limitations were slowing down the research process. One in particular was the archaic way lab animals are tagged and tracked. We were both using small metal ear tags, which were very hard to read when the animal was moving around the cage. After reading the tag, the information about the animal then had to be manually updated every time we ran an experiment. Needless to say the inefficient system was prone to error and time consuming. The frustration that we shared ignited our quest toward entrepreneurship. We began brainstorming that day and decided that we could use advanced technology to streamline the process and save researchers time, improve accuracy, and reduce cost. Continue reading

High Resolution NMR and Formulation of Biologics

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By Subhabrata Majumder and Arun Alphonse Ignatius

Biologics can suffer from inherent long term storage stability problems. Thus optimal  formulation of biologics is essential for maximizing its shelf life. Formulation development of biologics presents unique challenges which could be traced back to its inherent structural complexity. Continue reading

Mirror Mirror on the Wall: Which is the Purest Drug of All?

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By David Warmflash

Earlier this year, the Scripps Research Institute introduced a new, extremely effective method for making drugs selective to chirality.  This will be a milestone in a pharmaceutical world that’s growing ever more cognizant of the impact of drug stereochemistry, the 3-dimensional orientation of asymmetric, or chiral, carbon atoms. Continue reading