Drug Concentrations: A Critical Consideration for In Vitro Assays


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By Kenneth R. Brouwer

Ken Brouwer-finalIn vitro systems are used extensively in the drug discovery and drug development process. Utilizing minimal amounts of drug, they facilitate rapid screening for specific compound properties (efficacy, toxicity, distribution, elimination) and also help determine the mechanism of drug action. These simplified systems focus on the drug concentration in the incubation medium (e.g., microsomes, membrane vesicles), which may or may not be relevant to the concentration that occurs in vivo at the site of efficacy, toxicity, or elimination. Continue reading

Timely New eCourse on Good Oral Candidates


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By Sachin Lohani

Sachin Lohani-finalOral bioavailability, the fraction of an orally administered drug that reaches systemic circulation, is arguably the most important property in drug design and development. In contrast with the intravenous administration where the drug is directly and fully available in the bloodstream, orally administered drugs must be first absorbed in the gastro intestinal tract and then escape first-pass extraction to reach the systemic circulation and ultimately the site of action. Continue reading

Evolving Expectations with Transporter Assays: A Reality Check


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By Sid Bhoopathy

Sid Bhoopathy-finalIncreasing reliance on in vitro and modeling tools to predict the human pharmacological outcome of transporter interactions has raised their overall prominence. Both practitioners and regulators would ideally like these methodologies to have high translatable accuracy, reduce or eliminate the possibility of false negatives, and generate meaningful quantitative data without assay redundancy. Continue reading

The Importance and Benefits of Volunteering


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By Greg Amidon

Greg Amidon-finalVolunteering has always been a very important and incredibly rewarding part of my professional career and personal development. It has provided me with wonderful opportunities to develop close personal and professional friendships with many talented and well-respected pharmaceutical scientists and leaders in industry, academia, private practice, and government—relationships that have lasted a lifetime! It has also provided me an opportunity to impact pharmaceutical sciences in a way that goes beyond the walls of my place of employment. Continue reading

AAPS and Career Development: A Personal Perspective


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By Rakesh Gollen

Rakesh GollenGoing to graduate school in order to achieve your desired career can be challenging at some points. Learning about the job market and even the expectations of employers before starting the job search for oneself seems impossible. Being a final year graduate student in the Department of Pharmaceutical Sciences at Long Island University, New York, I perceive AAPS as a one-of-a-kind scientific society that fulfills every need for scientific knowledge and personal development through various volunteer opportunities offered year round. Continue reading


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