High Hopes? Or Smoke and Mirrors? Marijuana 106, Clinical Uses of Marijuana

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By Robert G. Bell

Robert BellThere are several cannabis derived pharmaceuticals, including dronadinaol, nabilone, and nabiximols (not available in the USA). Dronabinol and nabilone were approved in 1985 for the treatment of chemotherapy-induced nausea and vomiting in patients who have failed to respond adequately to conventional antiemetic therapy and for the treatment of anorexia associated with weight loss in patients with AIDS (dronabinol). Nabiximols is a cannabis-derived liquid extract oromucosal spray formulated from two strains of Cannabis sativa. Nabiximols is approved in Canada, New Zealand, and eight European countries for the symptomatic relief of spasticity in adults with multiple sclerosis who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy, the symptomatic relief of neuropathic pain in patients with multiple sclerosis, and intractable cancer pain. It is currently being evaluated in several clinical trials in the United States. Continue reading

AAPS TransSci101 eCourse: Making Drug Development More Successful

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By Meredith Weston

Meredith WestonI think it is safe to assume that all program managers have one common goal—meet the needs of your audience by providing exceptional programming that is both effective and convenient. That sixteen word statement, in a nutshell, is my professional purpose. Lucky for me, I’ve never had to attempt it alone. Continue reading

Electrically-Stimulated Drug Delivery

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By David Warmflash

David WarmflashThe ability to deliver pharmaceutical agents at precise body locations improves treatment efficacy by allowing larger drug doses in tissues where they are needed, while minimizing systemic effects. Novel, emerging methods of targeted drug delivery systems include passive and active nanoparticles. Made of lipoproteins, synthetic DNA, or other macromolecules, nanoparticle drug carriers are inserted into the body remotely from the target organ but are designed to unload the drug where it is needed. Various micro-pumps are also available and can be implanted to deliver drugs either into blood vessels for systemic treatment, into cerebrospinal fluid (intrathecal delivery) for central nervous system effects, or very locally to specific organs and tissues. Whether for systemic, regional, or local treatment, drug delivery must be extremely reliable and accurate, and now a new method meeting these requirements beckons: electrically-controlled drug release. Continue reading

Notable Impact in the Search for Molecules with Optimal Drug-Like Characteristics

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By Allen C. Templeton

Allen Templeton-finalDiscovering and developing molecules with optimal drug-like properties presents a number of notable challenges, yet it is key toward the long-term success of product development and value to patients. With most laboratories shifting away from the “shots on goal” strategy, there has been a renaissance in pharmaceutical sciences collaborating with discovery to design molecules optimized with drug-like properties from the outset. Challenges in the area include evaluating both new research techniques as well as strategy for implementation. Continue reading

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