Shake Up the Sectors: Increasing Mobility in the Pharmaceutical Sciences

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By Charlie Fehl

Charlie Fehl“Industry or academia?” The binary nature of the most commonly-asked question among chemistry Ph.D. students suggests a looming choice between two essential sectors driving the pharmaceutical sciences. However, the lines drawn amongst these camps are becoming increasingly blurred. Partnerships between pharma and academic groups are not new, but they are on the rise in the U.S. and Europe. Continue reading

Carded for Cold Medicine

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By Karen S. Pater and Colleen M. Culley

Karen Pater-finalColleen Culley-finalEach year in the United States, there are over a billion cases of the common cold, affecting all members in the household, including adults and children, leading to missed work and school. Common symptoms of the cold are nasal congestion, coughing, sneezing, and sore throat. Individuals frequently seek remedies for these symptoms at home or the pharmacy. The last thing that you want to do is to stand in line at the pharmacy to purchase an over-the-counter (OTC) medication. This has been the case for the past 10 years with products containing the popular oral decongestant pseudoephedrine, known by its generic name and the brand name Sudafed. What is the rationale for the restrictions? Continue reading

World Cancer Day: We Can. I Can.

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By Archana Akalkotkar

Archana AkalkotkarCancer is a battle no one chooses to fight. Cancer plays no favorites. It may attack the young or the aged, the healthy or the weak, and the rich or the poor. In 2012, the estimated deaths from cancer were around 8.2 million worldwide, and there are approximately 32.6 million people living with cancer (within 5 years of diagnosis). Continue reading

New Scientific Frontiers in Transporters: From the Bench to the Bedside

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By Patrick T. Ronaldson and Steven W. Louie

Patrick Ronaldson-finalSteven Louie-finalTransporters are critical determinants of drug disposition and drug efficacy. Research has identified and characterized multiple putative uptake and efflux transporters. For example, the ATP-dependent efflux transporter P-glycoprotein has been extensively studied in several normal and pathological cell types and is well known to be a critical determinant of tissue penetration for drugs. Other efflux transporter systems such as multidrug resistance proteins (Mrps) and breast cancer resistance protein (Bcrp) have been the subject of an intense research focus over the past decade. Continue reading

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