Accelerating Pharmaceutical Process Development

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By Balaji Bharatwaj, Sai Chamarthy, and Keirnan Lamarche

Balaji BharatwajSai Chamarthy-finalKeirnanLaMarcheBased on current data, it is estimated that about 27% of revenue is allocated by pharmaceutical companies toward process development and manufacturing; in some instances, more is spent on manufacturing than research and development. Presently, batch production processes dominant in the pharmaceutical industry have several advantages that include equipment flexibility and greater quality control, while rife with issues like mixing scalability and low operational asset efficiency. These shortfalls can be mitigated by the use of continuous manufacturing, an approach that can address issues pertinent to cost and robustness in pharmaceutical manufacturing. Continue reading

AAPS Pharmaceutical Science Roundup, May 2015

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image-final-croppedThis month’s roundup features stories on bogus cancer cures, the history of opiates, funding of embryo DNA modification, myths of big pharma, new vaccination deliveries, and how Yellowstone National Park relates to biotechnology!

Have a perspective on one of these stories? Submit your post to the AAPS Blog! Continue reading

Storage and Shipping of Biopharmaceuticals

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BY SATISH K. SINGH

Singh-finalBiotherapeutic drug substances are very often stored under frozen conditions to maximize their use period and decouple this use period from drug product shelf life. Almost all biotherapeutic drug products are labeled to be stored under refrigeration, although at early stages in development, these may also use frozen state storage. Continue reading

Ten Things Not to Miss in San Francisco

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By Angela Jackson

In preparation for the 2015 AAPS National Biotechnology Conference in San Francisco, one of the nicest things about visiting is that, although the city is “big” in terms of attractions and amenities, it is geographically small—only 49 square miles. Consequently, it is very easy to see and do a great many things in a short period of time. Continue reading

Being a ‘TDDP-FGite”: A Personal Vista

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BY URVI GALA

Urvi Gala-finalThe first question that comes to your mind is, what does TDDP FG stand for? Well, it’s the Targeted Drug Delivery and Prodrug focus group, which falls under the umbrella of the Physical Pharmacy and Biopharmaceutics section of AAPS. TDDP FG is an 11-year-old group that focuses on the enrichment of research and development efforts, primarily in the fields of targeted drug delivery and prodrugs. The group serves as an interdisciplinary platform, to share learnings and fortify the bond between academic researchers and pharmaceutical biotech companies. Continue reading

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